These sedatives, however, show two main disadvantages: (1) benzodiazepines and clomethiazole demonstrate a high misuse potential and (2) both medications can cause respiratory depression, especially in patients intoxicated with alcohol. ![]() However, clomethiazole is not registered in the USA. diazepam) or clomethiazole are recommended as a standard pharmacological treatment for the alcohol withdrawal syndrome (AWS) ( Schuckit, 1995 Mayo-Smith, 1997). ![]() Frequently, sedative drugs like benzodiazepines (e.g.
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